Role of microtubule dynamics in Wallerian degeneration and nerve regeneration after peripheral nerve injury
J Liu, L Li, Y Zou, L Fu, X Ma, H Zhang… - Neural regeneration …, 2022 - journals.lww.com
… explants, an in vitro model of Wallerian degeneration, with the … degeneration and Schwann
cell dedifferentiation, whereas nocodazole-induced microtubule destabilization inhibited …
cell dedifferentiation, whereas nocodazole-induced microtubule destabilization inhibited …
Neuron-Schwann cell interactions in peripheral nervous system homeostasis, disease, and preclinical treatment
JT Oliveira, C Yanick, N Wein… - Frontiers in Cellular …, 2023 - frontiersin.org
… In response to injury, Wallerian degeneration takes place. SCs dedifferentiate, proliferate,
and … A study demonstrated that Dabrafenib (10 uM), a Raf inhibitor, was able to inhibit the ErK …
and … A study demonstrated that Dabrafenib (10 uM), a Raf inhibitor, was able to inhibit the ErK …
Ascorbic acid accelerates Wallerian degeneration after peripheral nerve injury
L Li, Y Xu, X Wang, J Liu, X Hu, D Tan… - Neural Regeneration …, 2021 - journals.lww.com
… Schwann cells and macrophages are the main cells involved … Furthermore, ascorbic acid
inhibited myelin-associated … , promoting the dedifferentiation of Schwann cells, and enhancing …
inhibited myelin-associated … , promoting the dedifferentiation of Schwann cells, and enhancing …
Macrophages influence Schwann cell myelin autophagy after nerve injury and in a model of Charcot‐Marie‐Tooth disease
EM Weiß, M Geldermann, R Martini… - Journal of the …, 2023 - Wiley Online Library
… that Wallerian degeneration (WD) might be helpful as a model… and autophagic pathways
in the ex vivo model of WD, we … ” could plausibly foster SC dedifferentiation and subsequent …
in the ex vivo model of WD, we … ” could plausibly foster SC dedifferentiation and subsequent …
Protein kinase cα promotes proliferation and migration of Schwann cells by activating ERK signaling pathway
J Li, Z Zhang, J Wang, S Du, D Yao, R Cao, S Cui - Neuroscience, 2020 - Elsevier
… Wallerian degeneration (WD) and axon regeneration … Knockdown of PKCα inhibits SC
proliferation and migration in vitro… dedifferentiation or myelinophagy of SCs, but not be included in …
proliferation and migration in vitro… dedifferentiation or myelinophagy of SCs, but not be included in …
Dedifferentiation: inspiration for devising engineering strategies for regenerative medicine
Y Yao, C Wang - NPJ Regenerative medicine, 2020 - nature.com
… pathway is required for Schwann cell dedifferentiation following rat nerve … , extracellular
adenosine triphosphate inhibits rat Schwann cell proliferation and Schwann cell dedifferentiation …
adenosine triphosphate inhibits rat Schwann cell proliferation and Schwann cell dedifferentiation …
A glycolytic shift in Schwann cells supports injured axons
… axonal degeneration in vivo, referred to as Wallerian degeneration… death were obtained by
ex vivo extracellular flux analysis of … traditionally best known to ‘dedifferentiate’ and undergo a …
ex vivo extracellular flux analysis of … traditionally best known to ‘dedifferentiate’ and undergo a …
[HTML][HTML] Application of adipose-derived mesenchymal stem cells in an in vivo model of peripheral nerve damage
E González-Cubero… - Frontiers in Cellular …, 2022 - frontiersin.org
… the effect of TNF on Schwann cells (SCs) in vitro. Genes and their … Findings from our in vivo
and ex vivo model showed that … These immune cells assist Wallerian degeneration infiltrating …
and ex vivo model showed that … These immune cells assist Wallerian degeneration infiltrating …
Involvement of the miR-363-5p/P2RX4 axis in regulating Schwann cell phenotype after nerve injury
EJ Sohn, YK Nam, HT Park - International Journal of Molecular Sciences, 2021 - mdpi.com
… with the dedifferentiation of Schwann cells during the period of Wallerian degeneration
after … In contrast, overexpression from a P2RX4 plasmid in RT4 Schwann cells inhibited the …
after … In contrast, overexpression from a P2RX4 plasmid in RT4 Schwann cells inhibited the …
Increased TRPV4 expression in non-myelinating Schwann cells is associated with demyelination after sciatic nerve injury
… Incomplete demyelination is expected to inhibit nerve remyelination during the recovery
stage of sciatic nerve injury-induced Wallerian degeneration … Ex vivo sciatic nerve preparation …
stage of sciatic nerve injury-induced Wallerian degeneration … Ex vivo sciatic nerve preparation …